AstraZeneca shares drop on reports of $570b mega-merger

August 3, 2026 18:41 | News

AstraZeneca’s shares have fallen sharply as analysts and investors question the logic of a possible tie-up with Bristol Myers Squibb after reports they held preliminary talks about forming one of the world’s biggest drugmakers.

Shares in AstraZeneca were down 6.7 per cent in early trading on Monday in the UK, the biggest drop on the FTSE 100 index, ‌as investors and ‌analysts said Britain’s ⁠biggest drugmaker had little obvious need for a transformative acquisition despite ​potential financial benefits.

A person familiar with the matter told Reuters that AstraZeneca and Bristol had held talks, confirming an earlier Financial Times report.

On Friday, the two had a combined market capitalisation of nearly $US400 billion ($A569 billion), with AstraZeneca valued at $US264.11 billion and Bristol Myers at $US133.41 billion.

Vaccine for COVID-19 and AstraZeneca logo (file image)
AstraZeneca became a household name due to its vaccine work during the pandemic. (AP PHOTO)

“A combination with Bristol ⁠does not make strategic or financial sense,” said Markus ‌Manns, ​portfolio manager at Union Investment, an AstraZeneca shareholder.

“Many past mega-mergers have destroyed value and there ​is no apparent need ‌for Astra to do it.”

While AstraZeneca this year completed a direct ​listing on the New York Stock Exchange, underscoring its focus on its biggest market and its aim of benefiting from higher US valuations, a Bristol Myers deal would ​effectively ​mean a British company buying a major ​US pharmaceutical champion.

Manns said AstraZeneca CEO Pascal ‌Soriot had, in his 14 years at the helm, consistently prioritised research and development over cost-cutting.

“A merger would deeply disrupt a well-run company with a full pipeline,” he said.

Jefferies analysts said in a note they were puzzled by the reports of talks given AstraZeneca had a strong “growth ​and innovation profile”.

“If there is one company that doesn’t need financial engineering, it’s AstraZeneca,” they ​wrote.

AAP News

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